![]() It also has antioxidant and anti-inflammatory properties achieved by regulating the release of pro-inflammatory cytokines 16, 17, 18. It has a crucial role in many biological processes 15 stabilizing biological membranes and regulating calcium flux. Taurine is present in our daily foods, and also in anti-fatigue energy soft drinks and energizers for athletes 12, 13, 14. Taurine, 2-aminoethane sulfonic acid, is the most abundant free amino acid in most animal tissues. It is hoped that therapeutic approaches to liver fibrosis and the management of cirrhosis could be developed by understanding the etiology of liver fibrosis and developing improved diagnostic tools. Many previous reports have shown that liver fibrosis can be reversed under certain conditions, with a restoration of near normal architecture 10, 11. When remedies are used for long periods, it is essential to protect against the development of fibrotic complications that are associated with hepatic injury. Many trials have been made with the aim of inhibiting the activation of hepatic stellate and Kupffer cells, because they act to propagate oxidative and inflammatory responses, and subsequently to stimulate many fibrogenic mediators 9. There is no FDA approved drug for liver fibrosis, although considerable efforts have been exerted to defeat liver fibrosis through the inhibition of common crucial pathways of the fibrogenesis process 8. Consequently, ECM accumulates in the liver and collagenolysis process continues 2, 3, 4, 5, eventually leading to cirrhosis with its complications of cancer and death 6, 7. Liver fibrosis is initiated by the activation of immune cells that secrete cytokines and growth factors, leading to the activation of hepatic stellate cells (HSCs) and subsequent collagen production. Liver fibrosis is a major health condition that can cause serious disease and death 1. We concluded that the anti-fibrotic effect of taurine was attributable to the modulation of the TLR4/NF-κB signaling. Docking studies were carried out to understand how taurine interacts inside TLR4-MD2 complex and it showed good binding with the hydrophobic binding site of MD2. The protein levels of IL-6, LPS, MyD88, MD2, CD14, TGF-β1 and TNF-α were determined. The anti-fibrotic effects of taurine were evaluated by investigating the expression of TLR4, NF-κB. The antioxidant potential of taurine was verified by a marked increase of GSH content and a reduction of MDA level in liver tissue. These results were confirmed by histopathological examinations and immunehistochemical inspection of α-SMA, caspase-3 and NF-κB. Both concomitant and late taurine treatment (100 mg/kg, IP, daily) significantly reduced the rise in serum ALT and AST activities and significantly reversed the decrease in serum albumin and total protein. The current study aimed at assessing the anti-fibrotic effect of taurine against thioacetamide induced liver fibrosis in rats through the modulation of toll like receptor 4/nuclear factor kappa B signaling pathway. Unfortunately, a standard treatment for liver fibrosis has not been approved yet due to its complicated pathogenesis. Liver fibrosis is a significant health problem that can cause serious illness and death.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |